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Not really. Some opinions vary, but I've done it in the past (for extended periods) and have not noticed any difference since I started buying boxes, keeping cigars seperated. Just keep any flavored cigars in a different humidor.
I'd be more worried about that Louisville air getting to them. Really though, this should not be a big deal. I have more brands in a humi than I can count. I do keep boxes separated but singles and fivers go in with the rest of the pool. I don't do flavored cigars so I don't have to worry about that.
Just don't drop an Acid or Lars Tetens next to a Davidoff Gran Cru. It may not effect the core flavours, but it will make a natural cigar reek of perfume dips and other disastrous things.
Basically just don't put any flavored cigars near your good cigars. That's why if you'll notice when you go to a cigar store they have a separate humidor for the flavored cigars. Unless those cigars are in tubes, still most of the time they still end up in a separate humidor just to be on the safe side