The only pests I encounter regularly are the horn-worms and cut-worms, and only during the time the plant is in the field.
On the scale that I grow each year (between 30 and 75 plants) I'm able to control them organically, i.e. pick and squish or BT.
During harvest it is essential to closely inspect every priming so that you don't miss one of the little bastards and hang him in the coloring barn to feast, been there and done that.
I've never had a single issue with tobacco beetles. I use traditional curing/fermenting techniques for the most part, but have made accommodations for my climate in the past. I don't use any intentional freezing or pesticides, though I do have some tobacco hanging in the garage attic that has undergone several freeze/thaw cycles. I get to smoke some of it this summer as it was a 3 year experiment, well see.